منابع مشابه
ATP6V0A1 polymorphism and microRNA-637: A pathogenetic role for microRNAs in essential hypertension at last?
As a complex (or polygenic) genetic trait, essential hypertension is determined by the interplay between many genetic variants and several environmental factors. Despite an enormous and continuous effort from the clinical and research communities, much of the genetics of essential hypertension remains elusive.1 The classic approach for identifying disease-causing genes, that is, linkage analyse...
متن کاملQjm9411-637-75970-8 637..641
In the field of health and medicine, there is a long tradition of collaboration between developing countries and Western nations. These collaborative efforts have embraced teaching, research, and provision of training and personnel, as well as donations of resources and technological help. In the late 1990s, the medical press began to allocate significant space in their journals to the issue of...
متن کاملA common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.
BACKGROUND The catecholamine release-inhibitor catestatin and its precursor chromogranin A (CHGA) may constitute "intermediate phenotypes" in the analysis of genetic risk for cardiovascular disease such as hypertension. Previously, the vacuolar H(+)-ATPase subunit gene ATP6V0A1 was found within the confidence interval for linkage with catestatin secretion in a genome-wide study, and its 3'-UTR ...
متن کاملMicroRNA-421 Gene Polymorphism in Gastric Carcinoma
BACKGROUND As a common malignant tumor, gastric carcinoma requires early diagnosis to improve treatment efficacy. MicroRNA (miR) molecules have highly conserved nucleotide sequences and can negatively regulate target gene expression at the translational level. miR-421 has been suggested to be related with gastric cancer occurrence. The gene polymorphism of miR-421, however, has not been reporte...
متن کاملMicroRNA-derived Fragment Length Polymorphism Assay
MicroRNA (miRNA) studies are experiencing a transition from basic research applications to clinical applications. However, the lack of reliable and sensitive miRNA detection methods has become a bottleneck in the process. Here, we report an absolute quantification method based on the competitive PCR amplification of specific miRNAs and synthetic RNA spike-ins in a single reaction. RNA spike-ins...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2011
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.111.960591